ABSTRACT
O hipotireoidismo subclínico primário é uma causa importante de hipercolesterolemia. Devido à alta incidência de dislipidemia na população atual, este estudo investiga a função tireoideana em pacientes clinicamente eutireoideos e que apresentam dificuldades em controlar o colesterol. Foram realizados exames de função da tireóide em 30 pacientes sem evidências clínicas de hipotireoidismo e com dislipidemia refratária a tratamento convencional. Estes pacientes apresentavam média de TSH de 10,53UI/mL, T4 livre de 0,63ng/dL, colesterol total de 269,17mg/dL, HDL de 34,03mg/dL e LDL de 181,70mg/dL. Após 3 meses de terapêutica com levotiroxina sódica na dose de 100 a 150 microgramas diários, as médias obtidas foram: TSH 1,93UI/mL, T4 livre 1,18ng/dL, colesterol total 201,77mg/dL, HDL 45,8mg/dL e LDL 125,1mg/dL, evidenciando significativa melhora no perfil lipídico destes indivíduos. Nossos resultados indicam que os pacientes com hipercolesterolemia secundária a hipoteireoidismo subclínico foram beneficiados com o tratamento da disfunção tireoideana.
Subclinical hypothyroidism is an important cause of hypercholesterolemia. Owing to the high incidence of dyslipidemia, this study investigates thyroid profile of patientsapparently euthyroid with disorders in the cholesterol metabolism. Thyroid function exams were performed on 30 patients with no clinical evidence of hypothyroidism who had failed ondislipidemic conventional therapy. These patients had the following average levels: TSH 10,53 mUI/mL, free T4 0,63ng/dL, total cholesterol 269,17 mg/dL, HDL 34,03 mg/dL and LDL 181,70 mg/dL. After 3 months of treatment with sodic levothyroxine, 100-150 micrograms/day, the average ranges were: TSH 1,93 mUI/mL, free T4 1,18 ng/dL, total cholesterol 201,77 mg/dL,HDL 45,8 mg/dL and LDL 125,1 mg/dL. It shows an improvement in the lipid profile. Our results indicate that patients with hypercholesterolemia caused by subclinical hypothyroidism were benefited by thyroid disfunction treatment.